Infections could worsen dementia

A staff of researchers, led by Prof Hugh Perry, studied irritation in mice that produce a neurodegenerative ailment which brings about progressive nerve cell injury in the brain comparable to that observed in Alzheimer’s and Parkinson’s.

They identified that early in the condition, immune cells attempt to defend nerve cells from harm. But if mice had an infection at the same time, the brain became much more inflamed, worsening condition.

Prof Hugh Perry, Professor of Experimental Neuropathology, explained: “The findings mirror what we are observing in individuals with Alzheimer’s illness in the clinic. We have identified proof that individuals with Alzheimer’s who have systemic infections, such as chest or urine infections, are more very likely to have more quickly decline in memory and pondering and much more severe signs.”

Researchers said the findings could offer a way to discover remedies to tackle inflmamation of the brain, as a way of slowing down the illness.

Prof Perry stated: “We are now seeking at whether or not our findings could give a new way-in to creating therapies to modify this altered immune response and the communication among peripheral irritation and primed immune cells in the brain. If this procedure is key to driving diseases like Alzheimer’s, then maintaining it in check could be a way to slow down the condition in folks.”

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