The only key adjustments I’d made to my life-style since coming off statins had been getting rid of sugar (including alcohol and starchy food items such as bread) and eating much more animal unwanted fat. Many experts now believe that sugar is emerging as a correct villain in the heart-condition story even though soon after decades of demonisation, saturated unwanted fat has been acquitted of causing heart disease by a recent “meta” evaluation of 70 research by Cambridge University.
Typically, I was eating red meat three or 4 times a week and enjoying butter, full-excess fat milk and lots of eggs. You would have believed that after 3 months on a diet program so substantial in saturated excess fat, my cholesterol would have shot back up to pre-statin levels — but no, it came down and has stayed down seven months on. Not only that, but my levels of LDL (so-known as undesirable cholesterol) have been also decrease than when I’d been on statins, and my ratio of HDL (so-called good cholesterol) to LDL was below four for the 1st time, an superb signal, according to health care wisdom.
Not that I cared about any of this.
Yes, it was the statins that initially lowered my cholesterol levels so significantly. But so what? I believe that higher cholesterol has been a scapegoat for as well prolonged. Yes, it may possibly, in some conditions, be an indicator of heart ailment but there is no evidence of a causal website link. In my view, higher complete blood cholesterol or large LDL ranges no much more trigger heart attacks than paramedics result in auto crashes, even though they are existing at the scene.
Just lowering cholesterol with medicines with no sorting out the dietary and life-style variables that in fact lead to heart ailment is nonsensical. In addition to, there are a lot of other, much more trustworthy indicators of heart-illness risk. What even more astonished my GP was that on these indicators I was now apparently greater off in other approaches than when I’d been on statins. My blood stress was down. For the very first time in years, I was slimmer, especially close to the stomach. My triglycerides — a kind of blood body fat with a causal website link to heart disease — were reduce than at any time in the preceding eight many years. My fasting blood glucose was at the optimum level, whereas a year earlier it had been as well large. My complete white blood count — a marker of inflammation — was decrease.
My blood check for a marker named glycated haemoglobin (A1c), higher ranges of which are associated with heart ailment and total mortality, had been bang on normal. Last but not least, my level of c-reactive protein (CRP) — a protein that rises in response to irritation — was incredibly reduced. So, biochemically, I was in outstanding form, far better than when I’d been on the statins. “Have you taken up running?” asked my bemused GP.
No, I’d always run. For years, I’d exercised 3 occasions a week, eaten loads of fish, refrained from smoking and experimented with to hold my pressure ranges lower. The only point I’d changed was my consumption of sugar and animal excess fat.
That verify-up was seven months ago and now, at 58, I’m not on a single tablet. My GP is pleased. I truly feel greater than I have in years and, at the very same time, deeply concerned about proposals advising even wider use of statins.
Till 2005, statins have been prescribed only to those with at least a thirty per cent or higher danger of getting a heart attack inside 10 years. This was then lowered to a 20 per cent threat. Now, draft NHS recommendations would have them dished out to people with just a ten per cent risk — in other words, most guys in excess of the age of 50 and most females more than the age of 60.
I am a vascular surgeon. Prior to founding a private clinic in Dorset 11 many years in the past, specialising in varicose veins, I worked in the NHS for 13 many years. Back then, I didn’t question healthcare guidance on cholesterol, and imagined statins had been a wonder drug. And so they probably are, for men who have heart ailment — not automatically because they lower cholesterol, but due to the fact they may reduce other dangers this kind of as the inflammation-marker CRP. Exercising, fat reduction and omega three dietary supplements also lower CRP.
But what about other groups — girls, the elderly and men and women like me who have not been diagnosed with heart illness? The evidence that we will benefit from cholesterol-decreasing medicines is ambiguous at very best. The 2011 Hunt 2 study, a single of the most latest and greatest, followed 52,000 men and girls in Norway aged twenty-74 with no pre-current heart ailment, for ten many years.
The final results for females had been crystal clear. The lower a woman’s complete cholesterol, the better her threat of dying, either of heart disease or anything at all else, including cancer. This displays findings in preceding research.
For males, large cholesterol was related with heart illness and death from other leads to. But so, also, was reduced cholesterol — below 5mmol/l. Yet again, this is only an association, not a causal website link. A assortment of amongst 5mmol/l and 7mmol/l was the optimum degree. Guess what? This is presently the national typical. In addition, several research have linked large cholesterol amounts with improved longevity in the elderly.
As for me, I have not been diagnosed with heart ailment, and no one in my household has had a heart assault. Nevertheless, all four of my paternal uncles and my sister have diabetes. Study from Canada, published final year in the BMJ, has shown that statins raise the chance of diabetes, so that provides me tiny faith. The controversy over these drugs was reignited last week when Prof Sir Rory Collins from Oxford University warned that doctors’ hesitancy about prescribing them to individuals at threat could expense lives.
GPs are, by definition, generalists. They really do not have time to study and analyse data from every single paper on every single health care problem. Even so, in a current survey by Pulse magazine, six in ten GPs opposed the draft proposal to lower the threat degree at which patients are prescribed statins. And 55 per cent said they would not get statins themselves or suggest them to a relative, based on the proposed new tips.
If that doesn’t communicate volumes, I don’t know what does.